distamycin a inhibits hmga1-binding to the p-selectin promoter and attenuates lung and liver inflammation during murine endotoxemiadistamycin抑制hmga1-binding p-selectin启动子和变弱在小鼠内毒素肺和肝脏炎症.pdfVIP

Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia 1,2 1 1,4 1 5 Rebecca M. Baron *, Silvia Lopez-Guzman , Dario F. Riascos , Alvaro A. Macias , Matthew D. Layne , 6 1 1,7 8 6 Guiying Cheng , Cailin Harris , Su Wol Chung , Raymond Reeves , Ulrich H. von Andrian , Mark A. Perrella1,2,3 1 Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Newborn Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Physiological Sciences, Pontificia Universidad Javeriana, Bogota, Colombia, 5 Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America, 6 CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, 7 School of Biological Sciences, University of Ulsan, Ulsan, South Korea, 8 Department of Biochemistry and Biophysics, Washington State University, Pullman, Washington, United States of America Abstract Background: The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes (‘‘enhanceosomes’’) that upregulate expression of select genes within the