distance from home to study clinic and risk of follow-up interruption in a cohort of hiv-1-discordant couples in nairobi, kenya距离研究诊所和后续中断的风险一群hiv-1-discordant夫妇在内罗毕,肯尼亚.pdfVIP

Distance from Home to Study Clinic and Risk of Follow- Up Interruption in a Cohort of HIV-1-Discordant Couples in Nairobi, Kenya 1 1 1,3 1,3 N. Jeanne Conley , Patricia B. Pavlinac , Brandon L. Guthrie *, Romel D. Mackelprang , 4 2 5 6 1,2,3 Anthony N. Muiru , Robert Y. Choi , Rose Bosire , Ann Gatuguta , Carey Farquhar 1 Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, 2 Department of Medicine, University of Washington, Seattle, Washington, United States of America, 3 Department of Global Health, University of Washington, Seattle, Washington, United States of America, 4 Harvard Medical School, Boston, Massachusetts, United States of America, 5 Kenya Medical Research Institute, Nairobi, Kenya, 6 Department of Public Health, Kenyatta University, Nairobi, Kenya Abstract Background: Longitudinal studies of HIV-1-infected individuals or those at risk of infection are subject to missed study visits that may have negative consequences on the care of participants and can jeopardize study validity due to bias and loss of statistical power. Distance between participant residence and study clinic, as well as other socioeconomic and demographic factors, may contribute to interruptions in patient follow-up. Methods: HIV-1-serodiscordant couples were enrolled between May 2007 and October 2009 and followed for two years in Nairobi, Kenya. At baseline, demographic and home location information was collected and linear distance from each participant’s home to the study clinic was determined. Participants were asked to return to the study clinic fo