dissociation of motor task-induced cortical excitability and pain perception changes in healthy volunteers离解电机task-induced皮质兴奋性和疼痛感知健康志愿者的变化.pdfVIP

Dissociation of Motor Task-Induced Cortical Excitability and Pain Perception Changes in Healthy Volunteers 1,2 1 1 1 1 Magdalena S. Volz , Mariana Mendonca , Fernando S. Pinheiro , Huashun Cui , Marcus Santana , Felipe Fregni1* 1 Laboratory of Neuromodulation, Department of Physical Medicine Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard ´ ´ ´ Medical School, Boston, Massachusetts, United States of America, 2 Charite Center for Neurology, Neurosurgery and Psychiatry, Campus Charite Mitte, Charite - ¨ Universitatsmedizin Berlin, Berlin, Germany Abstract Background: There is evidence that interventions aiming at modulation of the motor cortex activity lead to pain reduction. In order to understand further the role of the motor cortex on pain modulation, we aimed to compare the behavioral (pressure pain threshold) and neurophysiological effects (transcranial magnetic stimulation (TMS) induced cortical excitability) across three different motor tasks. Methodology/Principal Findings: Fifteen healthy male subjects were enrolled in this randomized, controlled, blinded, cross-over designed study. Three different tasks were tested including motor learning with and without visual feedback, and simple hand movements. Cortical excitability was assessed using single and paired-pulse TMS measures such as resting motor threshold (RMT), motor-evoked potential (MEP), intracortical facilitation (ICF), short in