drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone果蝇核糖体蛋白突变体控制组织生长非自治通过对前胸腺和蜕皮激素的影响.pdfVIP

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone 1,2 3 3 1 4¤ Jane I. Lin , Naomi C. Mitchell , Marina Kalcina , Elly Tchoubrieva , Mary J. Stewart , Steven J. 5 5 6 5 1,2,7. Marygold , Cherryl D. Walker , George Thomas , Sally J. Leevers , Richard B. Pearson , Leonie M. Quinn3.*, Ross D. Hannan1,2,7,8.* 1 Peter MacCallum Cancer Centre, East Melbourne, Australia, 2 Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Australia, 3 Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia, 4 Department of Biological Sciences, North Dakota State University, Fargo, North Dakota, United States of America, 5 Growth Regulation Laboratory, Cancer Research UK London Research Institute, London, United Kingdom, 6 University of Cincinnati Medical Center, Cincinnati, Ohio, United States of America, 7 Department of Biochemistry and Cell Biology, Monash University, Clayton, Australia, 8 School of Biomedical Sciences, The University of Queensland, Brisbane, Australia Abstract The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine how reductions in Rps could lead to tissue overgrowth, we took advantage of the observation that an RpS6 mutant dominantly suppresses the small rough eye phenotype in a cyclin E hypomorphic mutant (cycEJP). We demonstrated that th