dynamic replacement of histone h3 variants reprograms epigenetic marks in early mouse embryos动态替换组蛋白h3变异重组表观遗传标记在早期小鼠胚胎.pdfVIP

Dynamic Replacement of Histone H3 Variants Reprograms Epigenetic Marks in Early Mouse Embryos 1 2 2 1 Tomohiko Akiyama , Osamu Suzuki , Junichiro Matsuda , Fugaku Aoki * 1 Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan, 2 Laboratory of Animal Models for Human Diseases, National Institute of Biomedical Innovation, Ibaraki, Japan Abstract Upon fertilization, reprogramming of gene expression is required f