early lung function testing in infants with aortic arch anomalies identifies patients at risk for airway obstruction在婴儿早期肺功能测试与主动脉弓异常识别患者气道阻塞的风险.pdfVIP

Early Lung Function Testing in Infants with Aortic Arch Anomalies Identifies Patients at Risk for Airway Obstruction 1 1 2 3 ´ 1 Charles Christoph Roehr *, Silke Wilitzki , Bernd Opgen-Rhein , Karim Kalache , Hans Proquitte , ¨ 1, Gerd Schmalisch1 Christoph Buhrer ´ ¨ ´ ¨ 1 Department of Neonatology, Charite Universitatsmedizin Berlin, Berlin, Germany, 2 Department of Paediatric Cardiology, Charite Universitatsmedizin Berlin, Berlin, ´ ¨ Germany, 3 Department of Obstetrics and Prenatal Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany Abstract Background: Aortic arch anomalies (AAA) are rare cardio-vascular anomalies. Right-sided and double-sided aortic arch anomalies (RAAA, DAAA) are distinguished, both may cause airway obstructions. We studied the degree of airway obstruction in infants with AAA by neonatal lung function testing (LFT). Patients and Methods: 17 patients (10 RAAA and 7 DAAA) with prenatal diagnosis of AAA were investigated. The median (range) post conception age at LFT was 40.3 (36.6–44.1) weeks, median body weight 3400 (2320–4665) g. Measurements included tidal breathing flow-volume loops (TBFVL), airway resistance (Raw) by bodyplethysmography and the maximal expiratory flow at functional residual capacity (V9maxFRC) by rapid thoracic-abdominal compression (RTC) technique. V 9maxFRC was also expressed in Z-scores, based on published gender-, age and height-specific reference va