early mortality in adults initiating antiretroviral therapy (art) in low- and middle-income countries (lmic) a systematic review and meta-analysis成人早期死亡率开始抗逆转录病毒疗法(art)在低收入和中等收入国家(lmic)的系统回顾和荟萃分析.pdfVIP

Early Mortality in Adults Initiating Antiretroviral Therapy (ART) in Low- and Middle-Income Countries (LMIC): A Systematic Review and Meta-Analysis 1,2 2 1 1 1,3 Amita Gupta *, Girish Nadkarni , Wei-Teng Yang , Aditya Chandrasekhar , Nikhil Gupte , Gregory P. 4 5 1 Bisson , Mina Hosseinipour , Naveen Gummadi 1 School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, 2 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, 3 Johns Hopkins Clinical Trial Unit, Byramjee Jeejeebhoy Medical College, Pune, India, 4 School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 5 School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America Abstract Background: We systematically reviewed observational studies of early mortality post-antiretroviral therapy (ART) initiation in low- and middle-income countries (LMIC) in Asia, Africa, and Central and South America, as defined by the World Bank, to summarize what is known. Methods and Findings: Studies published in English between January 1996 and December 2010 were searched in Medline and EMBASE. Three independent reviewers examined studies of mortality within one year post-ART. An article was included if the study was conducted in a LMIC, participants were initiating ART in a non-clinical trial setting and were $15 years. Fifty studies were included; 38 (76%) from sub-Saharan Africa (SSA), 5 (10%) from Asia, 2 (4%) from the Americas, and 5 (10%) were multi-regional. Median follow-up time and pre-ART CD4 cell count ranged fro