early pandemic influenza (2009 h1n1) in ho chi minh city, vietnam a clinical virological and epidemiological analysis早期(2009年h1n1大流行性流感在胡志明市,越南临床病毒学和流行病学分析.pdfVIP

Early Pandemic Influenza (2009 H1N1) in Ho Chi Minh City, Vietnam: A Clinical Virological and Epidemiological Analysis Tran Tinh Hien1,2,3., Maciej F. Boni1,4,5.*, Juliet E. Bryant1,5., Tran Thuy Ngan1,3., Marcel Wolbers1,5, 1 2 2 1 1,2 Tran Dang Nguyen , Nguyen Thanh Truong , Nguyen Thi Dung , Do Quang Ha , Vo Minh Hien , Tran 1 1 1,2 2 2 Tan Thanh , Le Nguyen Truc Nhu , Le Thi Tam Uyen , Pham Thi Nhien , Nguyen Tran Chinh , Nguyen Van Vinh Chau2, Jeremy Farrar1,3,5, H. Rogier van Doorn1,3,5. 1 Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, 2 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, 3 Southeast Asian Infectious Diseases Clinical Research Network (SEAICRN, Jakarta, Indonesia, 4 MRC Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom, 5 Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom Abstract Background: To date, little is known about the initial spread and response to the 2009 pandemic of novel influenza A (‘‘2009 H1N1’’) in tropical countries. Here, we analyse the early progression of the epidemic from 26 May 2009 until the establishment of community transmission in the second half of July 2009 in Ho Chi Minh City (HCMC), Vietnam. In addition, we present detailed systematic viral clearance data on 292 isolated and treated patients and the first three cases of