early peritoneal immune response during echinococcus granulosus establishment displays a biphasic behavior早期腹腔免疫反应在棘球绦虫granulosus建立显示一个两相的行为.pdfVIP

Early Peritoneal Immune Response during Echinococcus granulosus Establishment Displays a Biphasic Behavior 1 ´ ´ 2 ´ 2 1 Gustavo Mourglia-Ettlin , Juan Martın Marques , Jose Alejandro Chabalgoity , Sylvia Dematteis * ´ ´ ´ 1 Catedra de Inmunologıa, Departamento de Biociencias, Facultad de Quımica, Universidad de la Republica, Montevideo, Uruguay, 2 Laboratory of Vaccine Research, ´ Departamento de Desarrollo Biotecnologico, Instituto de Higiene, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay Abstract Background: Cystic echinococcosis is a worldwide distributed helminth zoonosis caused by the larval stage of Echinococcus granulosus. Human secondary cystic echinococcosis is caused by dissemination of protoscoleces after accidental rupture of fertile cysts and is due to protoscoleces ability to develop into new metacestodes. In the experimental model of secondary cystic echinococcosis mice react against protoscoleces producing inefficient immune responses, allowing parasites to develop into cysts. Although the chronic phase of infection has been analyzed in depth, early immune responses at the site of infection establishment, e.g., peritoneal cavity, have not been well studied. Because during early stages of infection parasites are thought to be more susceptible to immune attack, this work focused on the study of cellular and molecular events triggered early in the peritoneal cavity of infected mice. Principal Findings: Data obtained showed disparat