early second-trimester serum mirna profiling predicts gestational diabetes mellitus中期妊娠早期血清microrna的分析预测妊娠期糖尿病.pdfVIP

Early Second-Trimester Serum MiRNA Profiling Predicts Gestational Diabetes Mellitus 1,2,4. 3. 4. 4 5 6 6 Chun Zhao , Jing Dong , Tao Jiang , Zhonghua Shi , Bin Yu , Yunlong Zhu , Daozhen Chen , 2 1,7 3 1,8 2 1,3 1,7 Junrong Xu , Ran Huo , Juncheng Dai , Yankai Xia , Shiyang Pan , Zhibin Hu *, Jiahao Sha 1 Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China, 2 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3 Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China, 4 Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, China, 5 Changzhou Maternity and Child Health Hospital, Changzhou, China, 6 Wuxi Maternity and Child Health Hospital, Wuxi, China, 7 Department of Histology and Embryology, Nanjing Medical University, Nanjing, China, 8 Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China Abstract Background: Gestational diabetes mellitus (GDM) is one type of diabetes that presents during pregnancy and significantly increases the risk of a number of adverse consequences for the fetus and mother. The microRNAs (miRNA) have recently been demonstrated to abundantly and stably exist in serum and to be potentially disease-specific. However, no reported study investigates the associations between serum miRNA and GDM. Methodology/Principal Findings: We systematically used the