effect of baseline hiv disease parameters on cd4+ t cell recovery after antiretroviral therapy initiation in kenyan women基线艾滋病的影响参数对cd4 + t细胞复苏后抗逆转录病毒疗法开始在肯尼亚的女性.pdfVIP

Effect of Baseline HIV Disease Parameters on CD4+ T Cell Recovery After Antiretroviral Therapy Initiation in Kenyan Women 1,2 2 2 3 2 Lyle R. McKinnon *, Makobu Kimani , Charles Wachihi , Nico J. Nagelkerke , Festus K. Muriuki , Anthony Kariri2, Richard T. Lester2,4¤, Lawrence Gelmon2,4, T. Blake Ball4,5,6, Francis A. Plummer2,4,7, Rupert Kaul1,2, Joshua Kimani2,4 1 Department of Medicine, University of Toronto, Toronto, Canada, 2 Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya, 3 Department of Community Medicine, United Arab Emirates University, Al Ain, United Arab Emirates, 4 Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada, 5 Department of Immunology, University of Manitoba, Winnipeg, Canada, 6 Laboratory of HIV Immunology, Public Health Agency of Canada, Winnipeg, Canada, 7 National Microbiology Lab, Public Health Agency of Canada, Winnipeg, Canada Abstract Background: Antiretroviral therapy (ART) for HIV infection reconstitutes the immune system and improves survival. However, the rate and extent of CD4+ T cell recovery varies widely. We assessed the impact of several factors on immune reconstitution in a large Kenyan cohort. Methodology/Principal Findings: HIV-infected female sex workers from a longitudinal cohort, with at least 1 year of pre- ART and 6 months of post-ART follow-up (n = 79), were enrolled in the current study. The median pre-ART follow-up was 4,040 days. CD4 counts were measured biannually and viral loads where available. The median CD4 count at ART initiation was 180 cells/ul, which increased to 339 cells/ul at the most recent study visit. The rate of CD4+ T cell increase on ART was 7.91 cell