effect of bmap-28 antimicrobial peptides on leishmania major promastigote and amastigote growth role of leishmanolysin in parasite survivalbmap-28抗菌肽对利什曼虫主要promastigote leishmanolysin的寄生虫生存和无鞭毛体增长的作用.pdfVIP

Effect of BMAP-28 Antimicrobial Peptides on Leishmania major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival 1 2 1 ˚ 2,3 ´4 Miriam A. Lynn , Jason Kindrachuk , Alexandra K. Marr , Havard Jenssen , Nelly Pante , Melissa R. 2 5,6 2 1 Elliott , Scott Napper , Robert E. Hancock , W. Robert McMaster * 1 Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Department of Medical Genetics, Vancouver, Canada, 2 Centre for Microbial Diseases and Immunity Research and the Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada, 3 Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark, 4 Department of Zoology, University of British Columbia, Vancouver, Canada, 5 Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada, 6 Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada Abstract Background: Protozoan parasites, such as Leishmania, still pose an enormous public health problem in many countries throughout the world. Current measures are outdated and have some associated drug resistance, prompting the search into novel therapies. Several innovative approaches are under investigation, including the utilization of host defence peptides (HDPs) as emerging anti-parasitic therapies. HDPs are characterised by their small size, amphipathic nature and cationicity, which induce permeabilization of cell membranes, whilst modulating the immune response of the host. Recently, members of the cathelicidin family