effect of control strategies on prevalence, incidence and re-infection of clonorchiasis in endemic areas of china控制策略对发病率的影响,发病率和再次感染支睾吸虫病的流行地区的中国.pdfVIP

Effect of Control Strategies on Prevalence, Incidence and Re-infection of Clonorchiasis in Endemic Areas of China 1 2,3 4 4 5 6 6 7 Min-Ho Choi , Sue K. Park , Zhimin Li , Zhuo Ji , Gui Yu , Zheng Feng , Longqi Xu , Seung-Yull Cho , 8 1,8 1 Han-Jong Rim , Soon-Hyung Lee , Sung-Tae Hong * 1 Department of Parasitology and Tropical Medicine and Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea, 2 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea, 3 Institute of Health Policy Management, Seoul National University, Seoul, Korea, 4 Heilongjiang Province Center for Disease Control and Prevention, Heilongjiang, China, 5 Zhaoyuan Center for Disease Control and Prevention, Heilongjiang, China, 6 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China, 7 Department of Molecular Parasitology, Sungkyunkwan University, Suwon, Korea, 8 Korea Association of Health Promotion, Seoul, Korea Abstract Background: A pilot clonorchiasis control project was implemented to evaluate the efficacies of various chemotherapy strategies on prevalence, incidence and re-infection in Heilongjiang Province, China. Methods and Findings: Seven intervention groups (14,139 residents, about 2000 in each group) in heavily or moderately endemic areas were subjected to repeated praziquantel administration from 2001 to 2004. In the selective chemotherapy groups, residents were examined for fecal eggs, and those who tested positive were treated with three doses of 25 mg/kg praziquantel at 5-hour-inte