effect of deep brain stimulation on parkinsons nonmotor symptoms following unilateral dbs a pilot study脑深部电刺激对帕金森nonmotor症状后单方面dbs试点研究.pdfVIP

SAGE-Hindawi Access to Research Parkinson’s Disease Volume 2011, Article ID 507416, 4 pages doi:10.4061/2011/507416 Clinical Study Effect of Deep Brain Stimulation on Parkinson’s Nonmotor Symptoms following Unilateral DBS: A Pilot Study Nelson Hwynn,1, 2 Ihtsham Ul Haq,1, 3 Irene A. Malaty,1 Andrew S. Resnick,1 Yunfeng Dai,4 Kelly D. Foote,1 Hubert H. Fernandez,1, 5 Samuel S. Wu,4 Genko Oyama,1 Charles E. Jacobson IV,1 Sung K. Kim,1 and Michael S. Okun1 1 Center for Movement Disorders Neurorestoration, College of Medicine, University of Florida, Gainesville, FL 32610, USA 2 Division of Neurology, Scripps Clinic Torrey Pines, La Jolla, CA 92037, USA 3 Department of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA 4 Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA 5 Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA Correspondence should be addressed to Michael S. Okun, okun@neurology.ufl.edu Received 23 June 2011; Accepted 30 September 2011 Academic Editor: Fabrizio Stocchi Copyright © 2011 Nelson Hwynn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Parkinson’s disease (PD) management has traditionally focused largely on motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are effective treatments for motor symptoms. Nonmotor symptoms (NMSs) may also profoundly affect the quality of life. The purpose of this pilot study was to evaluate NMS changes pre- and post- DBS utilizing two recently developed questionnaires. Methods. NMS-Q (questionnaire) and