effect of fish oil supplementation on fasting vascular endothelial function in humans a meta-analysis of randomized controlled trials鱼油补充剂对禁食血管内皮功能的影响在人类随机对照试验的荟萃分析.pdfVIP

Effect of Fish Oil Supplementation on Fasting Vascular Endothelial Function in Humans: A Meta-Analysis of Randomized Controlled Trials 1 2 1 Wei Xin , Wei Wei , Xiaoying Li * 1 First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, PR China, 2 Medical College of Nankai University, Tianjin, PR China Abstract Background: Effect of fish oil supplementation on flow-mediated dilation, an index of endothelial function in humans, remains controversial. We performed a meta-analysis to determine whether fish oil supplementation could improve endothelial function. Methods: Human intervention studies were identified by systematic searches of Medline, Embase, Cochrane’s library and references of related reviews and studies. A random-effect model was applied to estimate the pooled results. Meta- regression and subgroup analyses were performed to evaluate the impact of study characteristics on the effect of fish oil supplementation on flow-mediated dilation. Results: A total of sixteen records with 1,385 subjects were reviewed. The results of the pooled analysis showed that fish oil supplementation significantly improved flow-mediated dilation (weighed mean difference: 1.49%, 95% confidence interval 0.48% to 2.50%, p = 0.004). Meta-regression and subgroup analysis suggested that the quality of included studies were inversely related to the overall effect (regression coefficient = 21.60, p = 0.04), and the significance of the effect was mainly driven by the studies with relatively poor quality. Sensitivity analysis including only double-blind, placebo-controlled studies indicated fish oil supplementation has no significant effect on endothelial function (weighed mean difference: 0.54%, 95% confidence interval 20.25% to 1.33%, p = 0.1