efficacy and safety of single and double doses of ivermectin versus 7-day high dose albendazole for chronic strongyloidiasis单引号和双剂量的伊维菌素的临床疗效和安全性与7天高剂量阿苯达唑为慢性类圆线虫病.pdfVIP

Efficacy and Safety of Single and Double Doses of Ivermectin versus 7-Day High Dose Albendazole for Chronic Strongyloidiasis 1 1 1 1 Yupin Suputtamongkol *, Nalinee Premasathian , Kid Bhumimuang , Duangdao Waywa , Surasak 1 1 2 3 Nilganuwong , Ekkapun Karuphong , Thanomsak Anekthananon , Darawan Wanachiwanawin , Saowaluk Silpasakorn1 1 Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2 Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 3 Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Abstract Background: Strongyloidiasis, caused by an intestinal helminth Strongyloides stercoralis, is common throughout the tropics. It remains an important health problem due to autoinfection, which may result in hyperinfection and disseminated infection in immunosuppressed patients, especially patients receiving chemotherapy or corticosteroid treatment. Ivermectin and albendazole are effective against strongyloidiasis. However, the efficacy and the most effective dosing regimen are to be determined. Methods: A prospective, randomized, open study was conducted in which a 7-day course of oral albendazole 800 mg daily was compared with a single dose (200 microgram/kilogram body weight), or double doses, given 2 weeks apart, of ivermectin in Thai patients with chronic strongyloidiasis. Patients were followed-up with 2 weeks after initiation of treatment, then 1 month, 3 months, 6 months, 9 mont