electrical stimulation to conductive scaffold promotes axonal regeneration and remyelination in a rat model of large nerve defect电刺激对导电支架促进轴突再生和remyelination在大鼠模型神经缺陷.pdfVIP

Electrical Stimulation to Conductive Scaffold Promotes Axonal Regeneration and Remyelination in a Rat Model of Large Nerve Defect 1. 2. 3. 1. 1,4 1 5 Jinghui Huang , Lei Lu , Jianbin Zhang , Xueyu Hu , Yongguang Zhang , Wei Liang , Siyu Wu , Zhuojing Luo1* 1 Institute of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi’an, China, 2 Department of oral anatomy and physiology, School of Stomatology, The Fourth Military Medical University, Xi’an, China, 3 Department of Occupational and Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi’an, China, 4 Fuzhou General Hospital, Fuzhou, China, 5 Department of Orthopaedics, Daping Hospital, The Third Military Medical University, Chongqing, China Abstract Background: Electrical stimulation (ES) has been shown to promote nerve regeneration when it was applied to the proximal nerve stump. However, the possible beneficial effect of establishing a local electrical environment between a large nerve defect on nerve regeneration has not been reported in previous studies. The present study attempted to establish a local electrical environment between a large nerve defect, and examined its effect on nerve regeneration and functional recovery. Methodology/Findings: In the present study, a conductive scaffold was constructed and used to bridge a 15 mm sciatic nerve defect in rats, and intermittent ES (3 V, 20 Hz) was applied to the conductive scaffold to establish an electrical environment at the site of nerve defect. Nerve regeneration and functional