ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium异位淋巴结构支持正在进行的生产class-switched自身抗体在类风湿性滑膜.pdfVIP

PLoS MEDICINE Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium 1[ 1[ 1 1 1 2 Frances Humby , Michele Bombardieri , Antonio Manzo , Stephen Kelly , Mark C. Blades , Bruce Kirkham , 3 1* Jo Spencer , Costantino Pitzalis 1 William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London, United Kingdom, 2 Department of Rheumatology, Kings College London, Guy’s Hospital, St Thomas Street, London, United Kingdom, 3 Division of Infection, Immunity and Inflammatory Diseases, Kings College London, Guy’s Hospital, St Thomas Street, London, United Kingdom Funding: This work was supported A B S T R A C T by grants from Guy’s and St Thomas’ Charity (FH), the Arthritis Research Campaign (MB) and INNOCHEM (Innovative Chemokine-based Background Therapeutic Strategies for Auto- immunity and Chronic inflammation) Follicular structures resembling germinal centres (GCs) that are characterized by follicular EU Framework Programme 6 (AM). dendritic cell (FDC) networks have long been recognized in chronically inflamed tissues in Funders did not have any role in study design, data collection and autoimmune diseases, including the synovium of rheumatoid arthritis (RA). However, it is analysis, decision to publish or in the debated whether these ectopic structures promote autoimmunity and chronic inflammation preparation of the manuscript. driving the production of pathogen