elevated adaptive immune responses are associated with latent infections of wuchereria bancrofti高适应性免疫反应与班氏丝虫的潜伏感染.pdfVIP

Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti 1. 1. 1 1,2 1 Kathrin Arndts , Susanne Deininger , Sabine Specht , Ute Klarmann , Sabine Mand , 1 3,4 3 3 5 Tomabu Adjobimey , Alexander Y. Debrah , Linda Batsa , Alexander Kwarteng , Christian Epp , 6 3,4 1 * 1 Mark Taylor , Ohene Adjei , Laura E. Layland , Achim Hoerauf 1 Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany, 2 Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany, 3 Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, 4 Faculty of Allied Health Sciences, Department of Theoretical and Applied Biology, and School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, ¨ ¨ 5 Department fur Infektiologie, Parasitologie, Universitatsklinikum Heidelberg, Heidelberg, Germany, 6 Liverpool School of Tropical Medicine, Liverpool, United Kingdom Abstract In order to guarantee the fulfillment of their complex lifecycle, adult filarial nematodes release millions of microfilariae (MF), which are taken up by mosquito vectors. The current strategy to eliminate lymphatic filariasis as a public health problem focuses upon in