elucidation of the glucose transport pathway in glucose transporter 4 via steered molecular dynamics simulations说明葡萄糖运输途径的葡萄糖转运蛋白4通过操纵分子动力学模拟.pdfVIP

Elucidation of the Glucose Transport Pathway in Glucose Transporter 4 via Steered Molecular Dynamics Simulations Aswathy Sheena, Suma S. Mohan, Nidhina Pachakkil A. Haridas, Gopalakrishnapillai Anilkumar* Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, India Abstract Background: GLUT4 is a predominant insulin regulated glucose transporter expressed in major glucose disposal tissues such as adipocytes and muscles. Under the unstimulated state, GLUT4 resides within intracellular vesicles. Various stimuli such as insulin translocate th