effect of hyperoxia and hypercapnia on tissue oxygen and perfusion response in the normal liver and kidney氧过多和血碳酸过多症组织灌注和氧反应在正常肝脏和肾脏.pdfVIP

Effect of Hyperoxia and Hypercapnia on Tissue Oxygen and Perfusion Response in the Normal Liver and Kidney Hai-Ling Margaret Cheng1,2,3* 1 Physiology Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada, 2 Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada, 3 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada Abstract Objective: Inhalation of air with altered levels of oxygen and carbon dioxide to manipulate tissue oxygenation and perfusion has both therapeutic and diagnostic value. These physiological responses can be measured non-invasively with magnetic resonance (MR) relaxation times. However, interpreting MR measurements is not straight-forward in extra-cranial organs where gas challenge studies have only begun to emerge. Inconsistent results have been reported on MR, likely because different organs respond differently. The objective of this study was to elucidate organ-specific physiological responses to gas challenge underlying MR measurements by investigating oxygenation and perfusion changes in the normal liver and kidney cortex. Materials and Methods: Gas challenges (100% O , 10% CO , and carbogen [90% O + 10% CO ]) interleaved with room air 2 2 2 2 was delivered to rabbits to investigate their effect on tissue oxygenation and perfusion. Real-time fiber-optic measurements of absolute oxygen and relative blood flow were made in the liver and kidney cortex. Results: Only the liver demonstrated a vasodilatory response to CO . Perfusion changes to other gases were minimal in both 2 organs. Tissue oxygenation