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group b streptococcus gapdh is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophagesb群链球菌gapdh释放细胞溶菌作用,同事与细菌表面,并在小鼠巨噬细胞凋亡
Group B Streptococcus GAPDH Is Released upon Cell
Lysis, Associates with Bacterial Surface, and Induces
Apoptosis in Murine Macrophages
1,2,3,4 1,2 ´ 1,2 3,4
Liliana Oliveira , Pedro Madureira , Elva Bonifacio Andrade , Abdelouhab Bouaboud , Eric
5 1,2 3,4 5 5
Morello , Paula Ferreira , Claire Poyart , Patrick Trieu-Cuot , Shaynoor Dramsi *
ˆ ´
1 Universidade do Porto, ICBAS-Instituto de Ciencias Biomedicas de Abel Salazar, Porto, Portugal, 2 IBMC-Instituto de Biologia Molecular e Celular, Porto, Portugal,
´ ´ ´ ´
3 Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite, Faculte de Medecine, Centre National de la Recherche Scientifique (UMR 8104), Paris, France, 4 Institut
´ ´ ´ ´ ` `
National de la Sante et de la Recherche Medicale, U1016, Paris, France, 5 Institut Pasteur, Unite de Biologie des Bacteries Pathogenes a Gram-positif, CNRS URA 2172, Paris,
France
Abstract
Glyceraldehyde 3-phosphate dehydrogenases (GAPDH) are cytoplasmic glycolytic enzymes that, despite lacking identifiable
secretion signals, have been detected at the surface of several prokaryotic and eukaryotic organisms where they exhibit
non-glycolytic functions including adhesion to host components. Group B Streptococcus (GBS) is a human commensal
bacterium that has the capacity to cause life-threate
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