normalized cut group clustering of resting-state fmri data归一化减少组静息状态功能磁共振成像数据的聚类.pdfVIP

Normalized Cut Group Clustering of Resting-State fMRI Data Martijn van den Heuvel*, Rene Mandl, Hilleke Hulshoff Pol Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands Abstract Background: Functional brain imaging studies have indicated that distinct anatomical brain regions can show coherent spontaneous neuronal activity during rest. Regions that show such correlated behavior are said to form resting-state networks (RSNs). RSNs have been investigated using seed-dependent functional connectivity maps and by using a number of model-free methods. However, examining RSNs across a group of subjects is still a complex task and often involves human input in selecting meaningful networks. Methodology/Principal Findings: We report on a voxel based model-free normalized cut graph clustering approach with whole brain coverage for group analysis of resting-state data, in which the number of RSNs is computed as an optimal clustering fit of the data. Inter-voxel correlations of time-series are grouped at the individual level and the consistency of the resulting networks across subjects is clustered at the group level, defining the group RSNs. We scanned a group of 26 subjects at rest with a fast BOLD sensitive fMRI scanning protocol on a 3 Tesla MR scanner. Conclusions/Significance: An optimal group clustering fit revealed 7 RSNs. The 7 RSNs included motor/visual, auditory and attention networks and the frequently reported default mode network. The found RSNs showed large overlap with recently reported resting-state results and support the idea of the formation of spatially distinct RSNs during rest in the human brain. Citation: van den Heuvel M, Mandl R, Hulshoff Pol H (2008) Normalized Cut Group Clustering of Resting-State fMRI Data. PLoS O