norovirus gastroenteritis, carbohydrate receptors, and animal models诺瓦克病毒胃肠炎、碳水化合物受体和动物模型.pdfVIP

Pearls Norovirus Gastroenteritis, Carbohydrate Receptors, and Animal Models Ming Tan, Xi Jiang* Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America HBGAs Are an Important Factor in Norovirus ed to recognize a carbohydrate receptor. In genus Norovirus , the Evolution bovine norovirus (GIII) was recently shown to interact with HBGAs [11], while the murine norovirus (MNV, GV) recognizes Noroviruses, an important cause of acute gastroenteritis in the sialic acid [12]. In addition, the feline calicivirus (FCV) in humans, have been found to recognize the histo-blood group genus Vesivirus uses the sialic acid on the host cell surface as a antigens (HBGAs) as receptors. Different noroviruses revealed receptor, most likely for attachment [13]. Another receptor or co- different receptor-binding profiles associated with the ABO, receptor on the host cellular membrane, the junctional adhesion secretor, and Lewis HBGA types. Direct evidence of HBGA molecule-1 (JAM-1), was found to be required in FCV infection, receptor recognition in viral infection and tropism was obtained probably helping virion penetration into host cells following the from human volunteer challenge studies on the prototype Norwalk initial attachment [14]. Furthermore, the newly discovered rhesus virus, in which the infection rates of the volunteers matched well monkey calicivirus, the Tulane virus, that was isolated from with the