npy neuron-specific y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in micenpy特异性神经元y2受体调节脂肪组织和骨小梁但不是皮质骨在老鼠体内平衡.pdfVIP

NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice 1 1 1 1,3 1 1 Yan-Chuan Shi , Shu Lin , Iris P. L. Wong , Paul A. Baldock , Aygul Aljanova , Ronaldo F. Enriquez , 1 1 2 1 1 1 Lesley Castillo , Natalie F. Mitchell , Ji-Ming Ye , Lei Zhang , Laurence Macia , Ernie Yulyaningsih , 1 1 1,3. 1,4 . Amy D. Nguyen , Sabrina J. Riepler , Herbert Herzog , Amanda Sainsbury * 1 Neuroscience Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia, 2 Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia, 3 Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia, 4 School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia Abstract Background: Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-mediated effects on energy homeostasis and bone physiology. Y2 receptors are located post-synaptically as well as acting as auto receptors on NPY- expressing neurons, and the different roles of these two populations of Y2 receptors in the regulation of energy homeostasis and body composition are unclear. Methodology/Principal Findings: We thus generated two conditional knockout mouse models, Y2lox/lox and NPYCre/