nrfl-1, the c. elegans nherf orthologue, interacts with amino acid transporter 6 (aat-6) for age-dependent maintenance of aat-6 on the membranenrfl-1,秀丽隐杆线虫nherf orthologue,与氨基酸转运蛋白6(aat-6)年龄相关性维护aat-6膜.pdfVIP

NRFL-1, the C. elegans NHERF Orthologue, Interacts with Amino Acid Transporter 6 (AAT-6) for Age-Dependent Maintenance of AAT-6 on the Membrane 1,2 1. 1. 1 1 Kohei Hagiwara , Shushi Nagamori , Yasuhiro M. Umemura , Ryuichi Ohgaki , Hidekazu Tanaka , 3,4 1 4,5 6 6 Daisuke Murata , Saya Nakagomi , Kazuko H. Nomura , Eriko Kage-Nakadai , Shohei Mitani , Kazuya Nomura4,5, Yoshikatsu Kanai1,4* 1 Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan, 2 School of Medicine, Osaka University, Osaka, Japan, 3 Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan, 4 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Saitama, Japan, 5 Department of Biological Sciences, Faculty of Sciences, Kyushu University, Fukuoka, Japan, 6 Department of Physiology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan Abstract + + The NHERF (Na /H exchanger regulatory factor) family has been proposed to play a key role in regulating transmembrane protein localization and retention at the plasma membrane. Due to the high homology between the family members, potential functional compensations have been a concern in sorting out the function of individual NHERF numbers. Here, we studied C. elegans NRFL-1 (C01F6.6) (nherf-like protein 1), the sole C. elegans orthologue of the NHERF family, which makes worm a model with low genetic redundancy o