on the relationship between sialomucin and sulfomucin expression and hydrogenotrophic microbes in the human colonic mucosa唾液黏蛋白和sulfomucin表达式之间的关系和hydrogenotrophic微生物在人类结肠粘膜.pdfVIP

On the Relationship between Sialomucin and Sulfomucin Expression and Hydrogenotrophic Microbes in the Human Colonic Mucosa 1 2 1¤ 2 3,6 Jennifer A. Croix , Franck Carbonero , Gerardo M. Nava , Mark Russell , Eugene Greenberg , H. Rex Gaskins1,2,4,5* 1 Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, 2 Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, 3 Department of Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, 4 Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, 5 Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, 6 Carle Foundation Hospital Institute for Digestive Health, Urbana, Illinois, United States of America Abstract The colonic mucus layer is comprised primarily of acidomucins, which provide viscous properties and can be broadly classified into sialomucins or sulfomucins based on the presence of terminating sialic acid or sulfate groups. Differences in acidomucin chemotypes have been observed in diseases such as colorectal cancer and inflammatory bowel disease, and variation in sialo- and sulfomucin content may influence microbial colonization. For example, sulfate derived from sulfomucin degradation may promote the colonization of sulfate-reducing bacteria (SRB), which through sulfate respiration generate the genotoxic gas hydrogen sulfide. Here, paired biopsies from right colon, left colon, and rectum of 20 subjects