results of gamma knife radiosurgery in acromegaly结果伽玛刀放射治疗肢端肥大症.pdfVIP

Hindawi Publishing Corporation International Journal of Endocrinology Volume 2012, Article ID 342034, 6 pages doi:10.1155/2012/342034 Clinical Study Results of Gamma Knife Radiosurgery in Acromegaly Alberto Franzin, Giorgio Spatola, Marco Losa, Piero Picozzi, and Pietro Mortini Department of Neurosurgery and Radiosurgery, Division of Neuroscience, IRCCS San Raff aele, 20132 Milan, Italy Correspondence should be addressed to Giorgio Spatola, spatola.giorgio@hsr.it Received 7 November 2011; Accepted 7 December 2011 Academic Editor: A. L. Barkan Copyright © 2012 Alberto Franzin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Single-session radiosurgery with Gamma Knife (GK) may be a potential adjuvant treatment in acromegaly. We analyzed the safety and efficacy of GK in patients who had previously received maximal surgical debulking at our hospital. Methods. The study was a retrospective analysis of hormonal, radiological, and ophthalmologic data collected in a predefined protocol from 1994 to 2009. The mean age at treatment was 42.3 years (range 22–67 yy). 103 acromegalic patients participated in the study. The median follow-up was 71 months (IQ range 43–107). All patients were treated with GK for residual or recurrent GH-secreting adenoma. Results. Sixty-three patients (61.2%) reached the main outcome of the study. The rate of remission was 58.3% at 5 years (95% CI 47.6–69.0%). Other 15 patients (14.6%) were in remission after GK while on treatment with somatostatin analogues. No serious side effects occurred after GK. Eight patients (7.8%) experienced a new deficit of pituitary functi