noise cancellation viral fine tuning of the cellular environment for its own genome replication噪音消除病毒微调自己的基因组复制的细胞环境.pdfVIP

Review Noise Cancellation: Viral Fine Tuning of the Cellular Environment for Its Own Genome Replication Yoshitaka Sato1,2,3, Tatsuya Tsurumi1,4* 1 Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Japan, 2 Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3 Department of Cell Biology, G-COE, Kobe University School of Medicine, Kobe, Japan, 4 Department of Oncology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan chromosomal DNA [11]. Only a small percentage of infected cells Abstract: Productive replication of DNA viruses elicits switch their states from the latent stage into the ‘‘lytic’’ cycle to host cell DNA damage responses, which cause both produce progeny viruses. EBV DNA replication occurs at discrete beneficial and detrimental effects on viral replication. In sites in nuclei called ‘‘replication compartments,’’ where all of the response to the viral productive replication, host cells viral replication proteins are assembled [12]. During lytic attempt to attenuate the S-phase cyclin-dependent kinase replication, the circular genome becomes a ready template for (CDK) activities to inhibit viral replication. However, amplification by the viral replication machinery, generating accumulating evidence regarding interactions between viral factors and cellular signaling molecules indicate that thousands of copies per cell. This reactivation is correlated with viruses utiliz