noise during rest enables the exploration of the brains dynamic repertoire休息期间噪声使探索大脑的动态曲目.pdfVIP

Noise during Rest Enables the Exploration of the Brain’s Dynamic Repertoire 1,2 3 4 ¨ 5,6 1,2,3 Anandamohan Ghosh *, Y. Rho , A. R. McIntosh , R. Kotter , V. K. Jirsa * 1Theoretical Neuroscience Group, Institut des Sciences du Mouvement, Marseille, France, 2 UMR6233, CNRS, Marseille, France, 3 Center for Complex Systems and Brain Sciences, Physics Department, Florida Atlantic University, Boca Raton, Florida, United States of America, 4 Rotman Research Institute of Baycrest Center, Toronto, Ontario, Canada, 5 Department of Cognitive Neuroscience, University Medical Centre St. Radboud, Nijmegen, The Netherlands, 6 Vogt Brain Research Institute and Anatomy II, ¨ Heinrich Heine University, Dusseldorf, Germany Abstract Traditionally brain function is studied through measuring physiological responses in controlled sensory, motor, and cognitive paradigms. However, even at rest, in the absence of overt goal-directed behavior, collections of cortical regions consistently show temporally coherent activity. In humans, these resting state networks have been shown to greatly overlap with functional architectures present during consciously directed activity, which motivates the interpretation of rest activity as day dreaming, free association, stream of consciousness, and inner rehearsal. In monkeys, it has been shown though that similar coherent fluctuations are present during deep anesthesia when there is no consciousness. Here, we show that comparable resting state networks emerge from a stability analysis of the network dynamics using biologically realistic primate brain connectivity, although anatomical information alone does