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Hindawi Publishing Corporation International Journal of Rheumatology Volume 2012, Article ID 369565, 5 pages doi:10.1155/2012/369565 Review Article Risk of Orthopedic Surgical Site Infections in Patients with Rheumatoid Arthritis Treated with Antitumor Necrosis Factor Alfa Therapy Bernardo Matos da Cunha,1 Licia Maria Henrique da Mota,2 and Leopoldo Luiz dos Santos-Neto3 1 Department of Internal Medicine, Hospital SARAH Brasılia, SARAH Network of Rehabilitation Hospitals, ´ SMHS Quadra 301 Bloco A, 70.335-901 Brasılia-DF, Brazil ´ 2 Department of Rheumatology, University of Brasılia, SGAN 605, Av. L2 Norte, 70840-901 Brasılia-DF, Brazil ´ ´ 3 Department of Internal Medicine, University of Brasılia, SGAN 605, Av. L2 Norte, 70840-901 Brasılia-DF, Brazil ´ ´ Correspondence should be addressed to Bernardo Matos da Cunha, bmcunha@sarah.br Received 27 October 2011; Accepted 15 December 2011 Academic Editor: Yehuda Shoenfeld Copyright © 2012 Bernardo Matos da Cunha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. International guidelines recommend interruption of anti-TNF medications in the perioperative period, but there are no randomized trials to support such recommendation. Objectives. To study literature evidence assessing the risk of surgical