role of calcium and mitochondria in mehg-mediated cytotoxicitymehg-mediated钙和线粒体的细胞毒性作用.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 248764, 15 pages doi:10.1155/2012/248764 Review Article Role of Calcium and Mitochondria in MeHg-Mediated Cytotoxicity Daniel Roos,1 Rodrigo Seeger,1 Robson Puntel,2 and Nilda Vargas Barbosa1 1 Departamento de Quımica, CCNE, Programa de Pos-Graduac¸ao em Bioquımica Toxicologica, Universidade Federal de Santa Maria, ´ ´ ˜ ´ ´ 97105.900 Santa Maria, RS, Brazil 2 Universidade Federal do Pampa-Campus Uruguaiana, BR-472 Km 7, 97500-970 Uruguaiana, RS, Brazil Correspondence should be addressed to Robson Puntel, robson puntel@.br and Nilda Vargas Barbosa, nvbarbosa@.br Received 6 April 2012; Revised 12 June 2012; Accepted 14 June 2012 Academic Editor: Marcelo Farina Copyright © 2012 Daniel Roos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Methylmercury (MeHg) mediated cytotoxicity is associated with loss of intracellular calcium (Ca2+ ) homeostasis. The imbalance in Ca2+ physiology is believed to be associated with dysregulation of Ca2+ intracellular stores and/or increased permeability of the biomembranes to this ion. In this paper we summarize the contribution of glutamate dyshomeostasis in intracellular Ca2+ overload and highlight the mitochondrial dysfunctions induced by MeHg via Ca2+ overload. Mitochondrial disturbances elicited by Ca2+ may involve several molecular events (i.e., alterations in the activity of the mitochondrial electron transport chain complexes, mitochondrial proton gradient diss