novel pandemic influenza a(h1n1) viruses are potently inhibited by das181, a sialidase fusion protein新甲型流感(h1n1)病毒由das181强有力地抑制,唾液酸酶融合蛋白.pdfVIP

Novel Pandemic Influenza A(H1N1) Viruses Are Potently Inhibited by DAS181, a Sialidase Fusion Protein 1 2 3 2 2 Gallen B. Triana-Baltzer , Larisa V. Gubareva , John M. Nicholls , Melissa B. Pearce , Vasiliy P. Mishin , 2 2 3 3 1 Jessica A. Belser , Li-Mei Chen , Renee W. Y. Chan , Michael C. W. Chan , Maria Hedlund , Jeffrey L. 1 1 2 2 1 Larson , Ronald B. Moss , Jacqueline M. Katz , Terrence M. Tumpey , Fang Fang * 1 NexBio, Inc., San Diego, California, United States of America, 2 Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 3 Departments of Pathology and Microbiology, University of Hong Kong, Pok Fu Lam, Hong Kong Special Administrative Region, People’s Republic of China Abstract Background: The recent emergence of a novel pandemic influenza A(H1N1) strain in humans exemplifies the rapid and unpredictable nature of influenza virus evolution and the need for effective therapeutics and vaccines to control such outbreaks. However, resistance to antivirals can be a formidable problem as evidenced by the currently widespread oseltamivir- and adamantane-resistant seasonal influenza A viruses (IFV). Additional antiviral approaches with novel mechanisms of action are needed to combat novel and resistant influenza strains. DAS181 (FludaseTM) is a sialidase fusion protein in early clinical development with in vitro a