role of forkhead transcription factors in diabetes-induced oxidative stressforkhead转录因子在diabetes-induced氧化应激中的作用.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2012, Article ID 939751, 7 pages doi:10.1155/2012/939751 Review Article Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress Bhaskar Ponugoti, Guangyu Dong, and Dana T. Graves School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104-6030, USA Correspondence should be addressed to Dana T. Graves, dtgraves@ Received 6 September 2011; Revised 11 October 2011; Accepted 26 October 2011 Academic Editor: Robert A. Harris Copyright © 2012 Bhaskar Ponugoti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications. The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO6 play important roles in the regulation of many cellular and biological processes and are critical regulators of cellular oxidative stress response pathways. FOXO1 transcription factors can affect a number of different tissues including liver, retina, bone, and cell types ranging from hepatocytes to microvascular endothelial cells and pericytes to osteoblasts. They are induced by oxidative stress and contribute to ROS-induced cell damage and apoptosis. In this paper, we discuss the role of FOXO transcription factors in mediating oxidative stress-induced cellular response. 1. Introduction