role of c-peptide in the regulation of microvascular blood flowc -肽在微血管血流量的调节.pdfVIP

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2008, Article ID 176245, 8 pages doi:10.1155/2008/176245 Review Article Role of C-Peptide in the Regulation of Microvascular Blood Flow 1, 2 3 1 2 ¨ 1 T. Forst, T. Kunt, B. Wilhelm, M. M. Weber, and A. Pfutzner 1 Medical Department, Institute for Clinical Research and Development, 55116 Mainz, Germany 2 Department of Endocrinolgy and Metabolism, Johannes Gutenberg University, 55131 Mainz, Germany 3 Diabetes Centre, 13187 Berlin, Germany Correspondence should be addressed to T. Forst, thomasf@ikfe.de Received 29 November 2007; Accepted 23 June 2008 Recommended by George King During the recent years, the role of C-peptide, released from the pancreatic beta cell, in regulating microvascular blood flow, has received increasing attention. In type 1 diabetic patients, intravenous application of C-peptide in physiological concentrations was shown to increase microvascular blood flow, and to improve microvascular endothelial function and the endothelial release of NO. + + C-peptide was shown to impact microvascular blood flow by several interactive pathways, like stimulating Na K ATPase or the endothelial release of NO. There is increasing evidence, that in patients with declining beta cell function, the lack of C-peptide secretion might play a putative role in the development of microvascular blood flow abnormalities, which go beyond the effects of declining insulin secretion or increased blood glucose levels. Copyright © 2008 T. Forst et al. This is an open access article distribute