role of nitrative and oxidative dna damage in inflammation-related carcinogenesis角色nitrative和氧化dna损伤的炎症相关的致癌作用.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 623019, 11 pages doi:10.1155/2012/623019 Review Article Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis Mariko Murata,1 Raynoo Thanan,1, 2 Ning Ma,3 and Shosuke Kawanishi2 1 Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Japan 2 Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, 513-8670, Japan 3 Faculty of Health Science, Suzuka University of Medical Science, Suzuka, 510-0293, Japan Correspondence should be addressed to Shosuke Kawanishi, kawanisi@suzuka-u.ac.jp Received 28 July 2011; Accepted 7 October 2011 Academic Editor: Vassilis Gorgoulis Copyright © 2012 Mariko Murata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chronic inflammation induced by biological, chemical, and physical factors has been found to be associated with the increased risk of cancer in various organs. We revealed that infectious agents including liver fluke, Helicobacter pylori, and human papilloma virus and noninfectious agents such as asbestos fiber induced iNOS-dependent formation of 8-nitroguanine and 8- oxo-7, 8-dihydro-2 -deoxyguanosine (8-oxodG) in cancer tissues and precancerous regions. Our results with the colocalization of phosphorylated ATM and γ-H2AX with 8-oxodG and 8-nitroguanine in inflammation-related cancer tissues suggest that DNA base damage leads to double-stranded breaks. It is interesting from the aspect of genetic instability. We also demonstrated IL-6