role of ppars and retinoid x receptors in the regulation of lung maturation and developmentppars和类维生素a x受体在调节肺成熟和发展.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2007, Article ID 91240, 8 pages doi:10.1155/2007/91240 Review Article Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and Development Dawn M. Simon1 and Thomas J. Mariani2 1 Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA 2 Division of Pulmonary Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA Received 6 March 2007; Accepted 9 May 2007 Recommended by Theodore J. Standiford Understanding lung development has significant importance to public health because of the fact that interruptions in the normal developmental processes can have prominent effects on childhood and adult lung health. It is widely appreciated that the retinoic acid (RA) pathway plays an important role in lung development. Additionally, PPARs are believed to partner with receptors of this pathway and therefore could be considered extensions of retinoic acid function, including during lung development. This review will begin by introducing the relationship between the retinoic acid pathway and PPARs followed by an overview of lung development stages and regulation to conclude with details on PPARs and the retinoic acid pathway as they may relate to lung development. Copyright © 2007 D. M. Simon and T. J. Mariani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. THE RETINOIC ACID PATHWAY AND PPAR thermore, nongenomic functions of PPARs upon gene regu-