scaffolds for growth factor delivery as applied to bone tissue engineering支架为生长因子应用于骨组织工程交付.pdfVIP

Hindawi Publishing Corporation International Journal of Polymer Science Volume 2012, Article ID 174942, 25 pages doi:10.1155/2012/174942 Review Article Scaffolds for Growth Factor Delivery as Applied to Bone Tissue Engineering Keith A. Blackwood,1 Nathalie Bock,1, 2, 3 Tim R. Dargaville,2 and Maria Ann Woodruff1 1 Biomaterials and Tissue Morphology Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4059, Australia 2 Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4059, Australia 3 Regenerative Medicine Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4059, Australia Correspondence should be addressed to Maria Ann Woodruff, mia.woodruff@.au Received 21 April 2012; Revised 3 September 2012; Accepted 25 September 2012 Academic Editor: Christopher Batich Copyright © 2012 Keith A. Blackwood et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There remains a substantial shortfall in the treatment of severe skeletal injuries. The current gold standard of autologous bone grafting from the same patient has many undesirable side effects associated such as donor site morbidity. Tissue engineering seeks to offer a solution to this problem. The primary requirements for tissue-engineered scaffolds have already been well established, and many materials, such as polyesters, present themselves as potential candidates for bone defects; they have comparable