selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats选择性雌激素受体调节剂调节树突棘在雄性老鼠的海马可塑性.pdfVIP

Hindawi Publishing Corporation Neural Plasticity Volume 2012, Article ID 309494, 6 pages doi:10.1155/2012/309494 Research Article Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats ´ 1, 2 2 ´ 1, 2 Ignacio Gonzalez-Burgos, Martha C. Rivera-Cervantes, Dulce A. Velazquez-Zamora, Alfredo Feria-Velasco,2 and Luis Miguel Garcia-Segura3 1 Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco 44340, Mexico ´ ´ 2 CUCBA, Universidad de Guadalajara, Guadalajara, Jalisco 45100, Mexico 3 Instituto Cajal, CSIC, 28002 Madrid, Spain Correspondence should be addressed to Luis Miguel Garcia-Segura, lmgs@cajal.csic.es Received 19 July 2011; Accepted 12 August 2011 Academic Editor: Irina Nikonenko ´ Copyright © 2012 Ignacio Gonzalez-Burgos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected