sex differences in vascular compliance in normal-weight but not obese boys and girls the effect of body composition性别差异在血管合规体重正常但不肥胖的男孩和女孩的身体成分的影响.pdfVIP

Hindawi Publishing Corporation International Journal of Pediatrics Volume 2012, Article ID 607895, 7 pages doi:10.1155/2012/607895 Clinical Study Sex Differences in Vascular Compliance in Normal-Weight but Not Obese Boys and Girls: The Effect of Body Composition Jeanie B. Tryggestad,1 David M. Thompson,2 Kenneth C. Copeland,1 and Kevin R. Short1 1 Section of Diabetes and Endocrinology, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA 2 Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA Correspondence should be addressed to Jeanie B. Tryggestad, jeanie-tryggestad@ Received 10 November 2011; Accepted 16 December 2011 Academic Editor: Lavjay Butani Copyright © 2012 Jeanie B. Tryggestad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. To determine the effect of sex and obesity on vascular function in children and explore potential mechanisms that account for differences in vascular function. Methods. Participants were 61 (30 boys) normal-weight (BMI 25–75% ile for age and sex) and 62 (30 boys) obese (BMI ≥ 95% ile) children of ages 8–18 years. Measurements of large and small artery elastic index (LAEI and SAEI, resp.) and reactive hyperemia index (RHI) were obtained at rest, along with anthropometric and biochemical information. Results. In normal-weight children, LAEI was 16% higher in males than females (P = 0.04) with a similar trend for SAEI (13% higher in males, P = 0.067). In obese children, no sex-related differences in vascular measures were observe