rhombencephalitis caused by listeria monocytogenes in humans and ruminants a zoonosis on the riserhombencephalitis单核细胞增多性李斯特氏菌所引起的人类和反刍动物的一种人畜共患病在上升.pdfVIP

Hindawi Publishing Corporation Interdisciplinary Perspectives on Infectious Diseases Volume 2010, Article ID 632513, 22 pages doi:10.1155/2010/632513 Review Article Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise? Anna Oevermann,1 Andreas Zurbriggen,1 and Marc Vandevelde2 1 Neurocenter, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland 2 Division of Clinical Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland Correspondence should be addressed to Anna Oevermann, anna.oevermann@itn.unibe.ch Received 4 August 2009; Accepted 25 November 2009 Academic Editor: Guey Chuen Perng Copyright © 2010 Anna Oevermann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Listeriosis is an emerging zoonotic infection of humans and ruminants worldwide caused by Listeria monocytogenes (LM). In both host species, CNS disease accounts for the high mortality associated with listeriosis and includes rhombencephalitis, whose neuropathology is strikingly similar in humans and ruminants. This review discusses the current knowledge about listeric encephalitis, and involved host and bacterial factors. There is an urgent need to study the molecular mechanisms of neuropathogenesis, which are poorly understood. Such studies will provide a basis for the development of new therapeutic strategies that aim to prevent LM from invading the brai