non-replication of genome-wide based associations between common variants in insig2 and pfkp and obesity in studies of 18,014 danesnon-replication常见变异之间的基于全基因组关联insig2仅pfkp和肥胖研究18014年的丹麦人.pdfVIP

Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes 1,2 1 1,3,4 5 Camilla H. Andreasen *, Mette S. Mogensen , Knut Borch-Johnsen , Annelli Sandbæk , Torsten 5 7 6 2 3 Lauritzen , Thorkild I. A. Sørensen , Lars Hansen , Katrine Almind , Torben Jørgensen , Oluf Pedersen1,4, Torben Hansen1 1 Steno Diabetes Center, Copenhagen, Denmark, 2 Medical and Science, Developmental Projects, Novo Nordisk A/S, Bagsværd, Denmark, 3 Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark, 4 Faculty of Health Science, University of Aarhus, Aarhus, Denmark, 5 Department of General Practice, University of Aarhus, Aarhus, Denmark, 6 Bristol-Myers Squibb Co., Princeton, New Jersey, United States of America, 7 Institute for Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark Abstract Background: The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (r