short bowel patients treated for two years with glucagon-like peptide 2 effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function短肠患者治疗两年glucagon-like肽2影响肠道形态和吸收,肾功能,骨骼和身体成分和肌肉功能.pdfVIP

Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2009, Article ID 616054, 12 pages doi:10.1155/2009/616054 Clinical Study Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Function P. B. Jeppesen,1, 2 P. Lund,1 I. B. Gottschalck,1 H. B. Nielsen,3 J. J. Holst,4 J. Mortensen,5 S.S. Poulsen,4 B. Quistorff,4 and P. B. Mortensen1 1 Department of Gastroenterology CA-2121, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark 2 Department of Medicine CA-2121, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark 3 Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark 4 Department of Biomedical Sciences, The Panum Institute, Nørre Alle 20, DK-2200 Copenhagen, Denmark 5 Department of Clinical Physiology and Nuclear Medicin, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Correspondence should be addressed to P. B. Jeppesen, bekker@dadlnet.dk Received 24 March 2009; Revised 22 June 2009; Accepted 25 June 2009 Recommended by Karel Geboes Background and aims. In a short-term study, Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients. This study describes longitudinal changes in relation to GLP-2 treatment for two years. Methods. GLP-2, 400 micrograms, s.c.,TID, were offered, to eleven SBS patients keeping parenteral support constant. 72-hour nutritional balance studies were performed at baseline, weeks 13, 26, 52 during two years intermitted by an 8-week washout period. In addition, mucosal morphometrics, renal function (by creatinine clearance), body composition and bone mineral density (by DEXA), biochemical m