risk of falls in parkinson’s disease a cross-sectional study of 160 patients下跌的风险帕金森病160例的横断面研究.pdfVIP

Hindawi Publishing Corporation Parkinson’s Disease Volume 2012, Article ID 362572, 10 pages doi:10.1155/2012/362572 Clinical Study Risk of Falls in Parkinson’s Disease: A Cross-Sectional Study of 160 Patients Ana Contreras1 and Francisco Grandas1, 2 1 Unidad de Investigacion en Trastornos del Movimiento, Instituto de Investigacion Sanitaria Hospital Gregorio Maranon, ´ ´ ˜ ´ 28007 Madrid, Spain 2 Servicio de Neurologıa, Hospital General Universitario Gregorio Maranon, C/ Doctor Esquerdo 46, 28007 Madrid, Spain ´ ˜ ´ Correspondence should be addressed to Francisco Grandas, fgrandasp@meditex.es Received 2 August 2011; Revised 5 September 2011; Accepted 23 September 2011 Academic Editor: Jan O. Aasly Copyright © 2012 A. Contreras and F. Grandas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Falls are a major source of disability in Parkinson’s disease. Risk factors for falling in Parkinson’s disease remain unclear. To determine the relevant risk factors for falling in Parkinson’s disease, we screened 160 consecutive patients with Parkinson’s disease for falls and assessed 40 variables. A comparison between fallers and nonfallers was performed using statistical univariate analyses, followed by bivariate and multivariate logistic regression, receiver-operating characteristics analysis, and Kaplan-Meier curves. 38.8% of patients experienced falls since the onset of Parkinson’s disease (recurrent in 67