rna polymerase ii elongation at the crossroads of transcription and alternative splicing转录的rna聚合酶ii伸长在十字路口和可变剪接.pdfVIP

SAGE-Hindawi Access to Research Genetics Research International Volume 2011, Article ID 309865, 9 pages doi:10.4061/2011/309865 Review Article RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing 1, 2 ˜ 1 ´ 1 1, 3 Manuel de la Mata, Manuel J. Munoz, Mariano Allo, Juan Pablo Fededa, Ignacio E. Schor,1 and Alberto R. Kornblihtt1 1 Laboratorio de Fisiologıa y Biologıa Molecular, Departamento de Fisiologıa, Biologıa Molecular, y Celular, IFIBYNE-CONICET, ´ ´ ´ ´ Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina 2 Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland 3 Department of Biology, Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland Correspondence should be addressed to Alberto R. Kornblihtt, ark@fbmc.fcen.uba.ar Received 15 June 2011; Accepted 23 June 2011 Academic Editor: Carles Sune Copyright © 2011 Manuel de la Mata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA process