solvent-free synthesis of new coumarins无溶剂合成新的香豆素.pdfVIP

Hindawi Publishing Corporation Organic Chemistry International Volume 2012, Article ID 828032, 8 pages doi:10.1155/2012/828032 Research Article Solvent-Free Synthesis of New Coumarins Redah I. Al-Bayati,1 Mahdi F. Radey,1 and Ahmed A. Al-Amiery2, 3 1 Chemistry Department, College of Science, Al-Mustansiriyah University, Baghdad 66004, Iraq 2 Applied Chemical Division, Department of Applied Science, University of Technology, Baghdad 10066, Iraq 3 Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Selangor, Bangi 43600, Malaysia Correspondence should be addressed to Ahmed A. Al-Amiery, dr.ahmed1975@ Received 26 March 2012; Accepted 4 June 2012 Academic Editor: Robert Salomon Copyright © 2012 Redah I. Al-Bayati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A solvent-free synthesis of five series of coumarin derivatives using microwave assistant is presented herein. The synthesized com- pounds are fully characterized by UV-VIS, FT-IR, and NMR spectroscopy. 1. Introduction Structure activity relationships of coumarin derivatives have revealed that the presence of substituted amino deriva- Coumarin (2H-Lbenzopyran-2-one) and its derivatives pos- tives is an essential feature of their pharmacological action. sess a wide range of various biological and pharmaceutical Based on these findings, we try to describe the synthesis of activities. They have a wide range of applications as antitu