specimen orientation by marking the peripheral end (potential) clinical advantages in prostate biopsy标本定位标记外围结束(潜在)在前列腺活检的临床优势.pdfVIP

Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 270403, 7 pages doi:10.1155/2011/270403 Review Article Specimen Orientation by Marking the Peripheral End: (Potential) Clinical Advantages in Prostate Biopsy Andrea Benedetto Galosi,1 Giovanni Muzzonigro,1 Vito Lacetera,1 and Roberta Mazzucchelli2 1 Institute of Urology, Azienda Ospedaliero Universitaria, United Hospitals, Torrette, 60126 Ancona, Italy 2 Section of Pathological Anatomy, School of Medicine, Marche Polytechnic University and Azienda Ospedaliero Universitaria, United Hospitals, 60126 Ancona, Italy Correspondence should be addressed to Andrea Benedetto Galosi, galosiab@yahoo.it Received 19 May 2011; Accepted 25 May 2011 Academic Editor: R. Montironi Copyright © 2011 Andrea Benedetto Galosi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The aim of this paper is to identify advantages that could be obtained by orientation of the biopsy specimen using the marking technique. We reviewed our experience (4,500 cases) and the published literature. The peripheral (proximal) end of the fresh specimen is marked with ink soon after needle delivering in a few minutes. It is performed easily in association with pre- embedding method. Five potential clinical advantages were identified: (1) tumor localization, (2) atypical lesions localization and planning rebiopsy strategy, (3) planning surgical strategy, (4) selection criteria for focal therapy and active surveillance, and (5) cost reduction. Peripheral end marking is low cost, easy and reproducible. It drives several potential a