selective interactions of valeriana officinalis extracts and valerenic acid with [3h]glutamate binding to rat synaptic membranes选择性的相互作用缬草提取物及含有谷类酸与[3 h]谷氨酸结合老鼠突触膜.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 403591, 7 pages doi:10.1155/2011/403591 Research Article Selective Interactions of Valeriana officinalis 3 Extracts and Valerenic Acid with [ H]Glutamate Binding to Rat Synaptic Membranes 1 ´ 2 3 Lisa M. Del Valle-Mojica, Yoshira M. Ayala-Marın, Carmen M. Ortiz-Sanchez, ´ 1 1 ´ 1 Bianca A. Torres-Hernandez, Safa Abdalla-Mukhaimer, and Jose G. Ortiz 1 Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico-Medical Sciences Campus, P.O. Box 365067, San Juan 00936-5067, Puerto Rico 2 Department of Biology, Natural Sciences Faculty, University of Puerto Rico Humacao Campus, Humacao 00791-4300, Puerto Rico 3 Department of Chemistry, Natural Sciences Faculty, University of Puerto Rico Cayey Campus, Cayey 00736-9997, Puerto Rico Correspondence should be addressed to Lisa M. Del Valle-Mojica, lisadelvalle@ Received 29 October 2010; Accepted 12 February 2011 Copyright © 2011 Lisa M. Del Valle-Mojica et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Although GABA neurotransmission has been suggested as a mechanism for Valeriana offi cinalis effects, CNS depression can also be evoked by inhibition of ionotropic (iGluR) and metabot