respiratory consequences of mild-to-moderate obesity impact on exercise performance in health and in chronic obstructive pulmonary disease呼吸道轻度到中度肥胖的后果在健康和运动性能的影响慢性阻塞性肺疾病.pdfVIP

Hindawi Publishing Corporation Pulmonary Medicine Volume 2012, Article ID 818925, 12 pages doi:10.1155/2012/818925 Review Article Respiratory Consequences of Mild-to-Moderate Obesity: Impact on Exercise Performance in Health and in Chronic Obstructive Pulmonary Disease Denis E. O’Donnell, Conor D. J. O’Donnell, Katherine A. Webb, and Jordan A. Guenette Respiratory Investigation Unit, Department of Medicine, Queen’s University and Kingston General Hospital, 102 Stuart Street, Kingston, ON, Canada K7L 2V6 Correspondence should be addressed to Denis E. O’Donnell, odonnell@queensu.ca Received 12 July 2012; Accepted 26 August 2012 Academic Editor: Darcy D. Marciniuk Copyright © 2012 Denis E. O’Donnell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In many parts of the world, the prevalence of obesity is increasing at an alarming rate. The association between obesity, multiple comorbidities, and increased mortality is now firmly established in many epidemiological studies. However, the link between obesity and exercise intolerance is less well studied and is the focus of this paper. Although exercise limitation is likely to be multifactorial in obesity, it is widely believed that the respiratory mechanical constraints and the attendant dyspnea are important contributors. In this paper, we examined the evidence that critical ventilatory constraint is a proximate source of exercise limitation in individuals with mild-to-moderate obesity. We first reviewed existing information on exercise performance, including ventilatory and perceptual response patterns, in obese individ