n-octanoyl-dopamine is an agonist at the capsaicin receptor trpv1 and mitigates is chemia-induced acute kidney injury in ratn-octanoyl-dopamine是辣椒素受体trpv1受体激动剂,降低chemia-induced急性肾损伤的老鼠.pdfVIP

N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat 1 2 1 2 Charalambos Tsagogiorgas *, Johannes Wedel , Maximilia Hottenrott , Michael O. Schneider , 3 3 3 4 4 Uta Binzen , Wolfgang Greffrath , Rolf-Detlef Treede , Bastian Theisinger , Sonja Theisinger , ¨ 2 ¨ 2 1 2 2 Rudiger Waldherr , Bernhard K. Kramer , Manfred Thiel , Peter Schnuelle , Benito A. Yard , Simone Hoeger2 1 Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany, 2 Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany, 3 Division of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany, 4 Novaliq GmbH, Heidelberg, Germany Abstract Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous N-acyl dopamine derivatives are able to activate TRPV1, we tested if synthetic N- octanoyl-dopamine (NOD) activates TRPV1 and if it improves AKI. These properties of NOD and its intrinsic anti- inflammatory character were compared with those of dopamine (DA). TRPV1 a